The Grim Adventures of Billy & Mandy — Season 4

At school, Billy, Mandy, and Irwin look for a club to join. Irwin plans to join the Macrame club to meet girls; Billy inquires on the Junior CIA club, which forcefully recruits him; Mandy joins the "Secret Snake Club", a snake-themed club consisting of three geeks. The nerds reveal that their "secret agenda" is to resurrect Shnissugah, a giant snake which lived hundreds of years ago in Canada, to take revenge against the popular kids, but they lack the power of the Underworld to do so. Mandy calls for Grim, who proceeds to revive Shnissugah through the internet. Billy, as a junior agent of the CIA, stops a criminal plan by Irwin, who was using the Macrame club for personal gain; and Shnissugah turns out to be a tiny, 8-cm (3.14-in) long, harmless snake.

When Billy and Mandy's school is preparing for a big game, Mindy entrusts the care of the school's mascot, Fluffy Cat, to Billy, to protect him from being kidnapped by the rival team, the Booty Heads. At Billy's house, Fluffy Cat is a disaster, so Billy's mom throws him into the basement, where the cat gets inside Grim's trunk, absorbing its powers. A giant Fluffy Cat appears just before the game wreaking havoc.

As Billy is tired of all the rules in his house, he cannot resist the urge to try his father's new motorcycle. The motorcycle breaks down, and Billy asks Grim to repair it. Grim's scythe turns the motorcycle into a wild, supernatural vehicle, which transforms Billy's parents and everyone around it into undead creatures and motorized monsters. Mandy makes Billy tell the truth about breaking the motorcycle in the first place, at which point his parents and everyone else return to normal.

After Billy's baseball team loses badly against Mindy's, Grim decides to coach them. Mandy is not allowed on the team, as Billy is reluctant to let girls play, although he does not realize Mindy is a girl too. Mandy puts on a baseball cap and, assuming the role of "Manfred", pitches for Billy's team anyway. With additional help from ghoulish players which played in the Underworld Little Leagues alongside Grim, Billy's team wins when Pud'n hits a home run.

While at Sassy Cat Land, the theme park dedicated to Sassy Cat (and to ridiculously long lines), Billy, Mandy, and Grim stumble upon a closed attraction, a futuristic "house of tomorrow". Inside, they find Master-Control, a sentient and autonomous, thinking, feeling artificial intelligence computer program claiming to know everything (and wishing death upon the trio when Billy angers him), and Tom Smith, a tour guide that became trapped in the house when it closed forty years ago. Tom explains that the attraction closed when a kid, actually Billy's dad, annoyed Master-Control with his dumb questions, and the robots started attacking the humans. Billy, Mandy and Grim exit the house unharmed, but Tom misses his opportunity to escape and is left behind again.

After a trip to the mall, Mandy becomes the spokesperson for Happy Huggy Stuffy Bears, a new stuffed toy in town. After the success of her commercial, Mandy gives away stuffed bears to other children, who start wreaking havoc in the city. Eris, the goddess of chaos, is behind the toys, which mind-control the children into creating chaos. Mandy decides not to share control of the world with Eris, and orders Grim to destroy the toys.

When Billy finally gets a "secret decoder ring" in his Blasto Bits cereal, he receives a holographic message from a strange creature who speaks about finding the "Secret of the Universe" in an abandoned mine shaft. All the other children of Endsville, also with decoder rings, race to the mine to be the first one to get the Secret. The entire effort is revealed to be a trap laid by Lubbermouth, a worm-like creature from Grim's past, who wishes to free herself from the curse of guarding the Secret. When Mindy looks down at the pit, she becomes the new guardian of the Secret and has to stay there forever.

One night a strange odor travels through the city, prompting the noses of all the people, including Billy's, to follow it. The next night, Mandy, who is noseless, and Grim decide to wait outside Billy's house for the event to repeat. When the odor reappears, the nose parade leads them to the shopping mall, where they meet a "Nasalmancer", a nose wizard who is trying to take over other people's noses since he lost his own. Billy recovers his nose, but slices it in two, and gives one half to the Nasalmancer.

When Billy goes into the mud for the fifth time in the day while wearing his white tuxedo before a wedding, Grim tries to figure out why Billy is so stupid. Billy's dad recounts Billy's life from his birth until he met Mandy and explains that Billy is not dumb, but actually a genius with a certified "Honorary Genius Degree". It is quite evident to Grim that Billy's problem is his equally dumb father.

After Grim's robe comes out of the washing machine, Billy and Mandy find Thromnambular, a talking skull with ruby eyes and a number nine imprinted on his forehead. Grim tells them that the skull is a magical artifact imprisoned on Earth that must grant his nine wishes to be free. When Mandy asks Grim why he has not used any of the wishes, Grim tells her that the skull will corrupt the wishes and end up affecting the wisher.

When Billy gets the opportunity to adopt one of four dogs, he says he wants them all. Grim uses his scythe to magically combine the dogs and create Billy's dream dog, who calls himself Wiggy Jiggy Jed. Although initially Billy and Jed are best friends, their relationship falls apart when Billy tells Jed to sleep outside. Jed uses the powers of Grim's trunk to build a giant machine to capture the beds of all people. Billy throws Jed a dish of primordial ooze and he dissolves.

To raise money to buy Sea-Critters (similar to Sea-Monkeys), Billy has a garage sale where he sells Grim's scythe to Irwin for less than two cents. With the great mystical strength and power of the scythe, Irwin hypnotizes Mandy and takes her on a romantic date. Billy and Grim try to recover the scythe, and when they do Mandy gets out of the trance. Irwin is punished by being transformed into a tiny sea-critter and placed in Billy's fish bowl.

When Billy gets under his house's foundation, he encounters again his "son", Jeff the Spider, who has just laid eggs. Jeff tries to make things right with Billy so he can take care of the baby spiders, as he is going to die after the eggs hatch. Naturally terrified of seeing Jeff, Billy runs away and a wild car chase ensues. The eggs hatch, and Grim decides to refill Jeff's hourglass that represents his lifetime so he does not die and can continue to scare Billy.

After seeing Billy, Mandy and Grim battling a strange creature, Irwin again feels rejected by Mandy. Hoss Delgado, spectral exterminator, appears to help Mandy destroy the monster. Delgado decides to have Irwin as his sidekick and train him to be "cool" to win Mandy's love. Irwin gets an attire like Delgado's, and attaches an egg beater to his right hand. Delgado releases a monster so Irwin can fight it and impress Mandy, but he is humiliated anyway. Mandy tells Irwin he is just a nerd, and Billy tries to assure him that being a nerd is not such a bad thing after all.